|
KMID : 0356620140290030312
|
|
Journal of Korean Society of Endocrinology
2014 Volume.29 No. 3 p.312 ~ p.319
|
|
|
Age Is the Strongest Effector for the Relationship between Estimated Glomerular Filtration Rate and Coronary Artery Calcification in Apparently Healthy Korean Adults
|
|
Chae Hyun-Beom
Lee Shin-Yeoung
Kim Nam-Hee
Han Ki-Joong
Lee Tae-Hoon
Jang Choel-Min
Yoo Kyung-Mo
Park Hae-Jung
Lee Min-Kyung
Jeon Won-Seon
Park Se-Eun
Moon Heui-Soo
Park Cheol-Young
Lee Won-Young
Oh Ki-Won
Park Sung-Woo
Rhee Eun-Jung
|
|
|
Abstract
|
|
|
Background: Chronic kidney disease (CKD) is considered one of the most common risk factors for cardiovascular disease. Coronary artery calcification (CAC) is a potential mechanism that explains the association between renal function and cardiovascular mortality. We aimed to evaluate the association between renal function and CAC in apparently healthy Korean subjects.
Methods: A total of 23,617 participants in a health-screening program at Kangbuk Samsung Hospital were included in the study. Estimated glomerular filtration rate (eGFR) was assessed using the Cockcroft-Gault equation. Coronary artery calcium score (CACS) was measured via multidetector computed tomography. Subjects were divided into three groups according to the CKD Staging system with eGFR grade: stage 1, eGFR ≥90 mL/min/1.73 m2; stage 2, eGFR 60 to 89 mL/min/1.73 m2; and stage 3, eGFR 30 to 59 mL/min/1.73 m2.
Results: The mean age of the participants was 41.4 years and the mean eGFR was 103.6±21.7 mL/min/1.73 m2. Hypertension and diabetes were noted in 43.7% and 5.5% of the participants, respectively. eGFR showed a weakly negative but significant association with CACS in bivariate correlation analysis (r=-0.076, P<0.01). Mean CACS significantly increased from CKD stage 1 to 3. The proportion of subjects who had CAC significantly increased from CKD stage 1 to 3. Although the odds ratio for CAC significantly increased from stage 1 to 3 after adjustment for confounding factors, this significance was reversed when age was included in the model.
Conclusion: In early CKD, renal function negatively correlated with the degree of CAC in Korean subjects. Age was the strongest effector for this association.
|
|
|
KEYWORD
|
|
|
Coronary artery calcification, Glomerular filtration rate, Renal insufficiency, chronic
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|